Appetite or weight changes. Significant weight loss or weight gain—a change of more than 5% of body weight in a month.The concept of mental illness has evolved over the centuries, with input and classifications provided from a number of different fields. Because depression and similar conditions were difficult to classify, they were often lumped together in a single category of inquiry. Throughout this evolutionary process, religion, culture, politics and science played significant roles in developing our understanding of depression.Depression is a serious issue which affects men and women of all ages. There are a variety of medications available to treat depression. If you aren't comfortable with the idea of taking medication or if your body doesn't react well to it, you can also take a holistic approach to your treatment. Sometimes holistic treatments are used in conjunction with medication as well. Try employing a few methods to see if you can effectively treat your depression holistically.